Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/26421
Título : Dendritic Cells from HIV-1 Infected Individuals are Less Responsive to Toll-like Receptor (TLR) Ligands
Autor : Martinson, Jeffrey A.
Román González, Alejandro
Tenorio, Allan R.
Montoya Guarín, Carlos Julio
Gichinga, Carolyne N.
Rugeles López, María Teresa
Tomai, Mark
Krieg, Arthur M.
Ghanekar, Smita
Baum, Linda L.
Landay, Alan L.
metadata.dc.subject.*: VIH
HIV
Receptor Toll-Like 8
Toll-Like Receptor 8
Receptor Toll-Like 7
Toll-like receptor 7
Infecciones por VIH
HIV Infections
Interferón-alfa
Interferon-alpha
Células Dendríticas
Dendritic Cells
Fecha de publicación : 2007
Editorial : Elsevier
Citación : Martinson JA, Roman-Gonzalez A, Tenorio AR, Montoya CJ, Gichinga CN, Rugeles MT, Tomai M, Krieg AM, Ghanekar S, Baum LL, Landay AL. Dendritic cells from HIV-1 infected individuals are less responsive to toll-like receptor (TLR) ligands. Cell Immunol. 2007 Nov-Dec;250(1-2):75-84. doi: 10.1016/j.cellimm.2008.01.007.
Resumen : ABSTRACT: We compared TLR responsiveness in PBMC from HIV-1-infected and uninfected individuals using the TLR agonists: TLR7 (3M-001), TLR8 (3M-002), and TLR7/8 (3M-011). Activation and maturation of plasmacytoid dendritic cells (pDC) were measured by evaluating CD86, CD40, and CD83 expression and myeloid dendritic cell (mDC) activation was measured by evaluating CD40 expression. All agonists tested induced activation and maturation of pDC in PBMC cultures of cells from HIV+ and HIV- individuals. The TLR7 agonist induced significantly less pDC maturation in cells from HIV+ individuals. Quantitative assessment of secreted IFN-alpha and pro-inflammatory cytokines at the single cell level showed that pDC from HIV+ individuals stimulated with TLR7 and TLR7/8 induced IFN-alpha. TLR8 and TLR7/8 agonists induced IL-12 and COX-2 expression in mDC from HIV+ and HIV- individuals. Understanding pDC and mDC activation and maturation in HIV-1 infection could lead to more rational development of immunotherapeutic strategies to stimulate the adaptive immune response to HIV-1.
metadata.dc.identifier.eissn: 1090-2163
ISSN : 0008-8749
metadata.dc.identifier.doi: 10.1016/j.cellimm.2008.01.007.
Aparece en las colecciones: Artículos de Revista en Ciencias Médicas

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