1. Repositorio Institucional Universidad de Antioquia
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  3. Instituto de Investigaciones Médicas
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Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/41216
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dc.contributor.authorAgudelo Goméz, Lee Solbay-
dc.contributor.authorTangarife Castaño, Verónica-
dc.contributor.authorBetancur Galvis, Liliana Amparo-
dc.contributor.authorZapata Londoño, María Bibiana-
dc.contributor.authorPérez Guaita, David-
dc.contributor.authorGonzález, Miguel-
dc.date.accessioned2024-08-18T15:24:28Z-
dc.date.available2024-08-18T15:24:28Z-
dc.date.issued2012-
dc.identifier.citationGonzález MA, Pérez-Guaita D, Agudelo-Goméz LS, Tangarife-Castaño V, Zapata B, Betancur-Galvis L. Synthesis and Biological Evaluation of Combretastatin A-4 and Three Combretastatin-Based Hybrids. Natural Product Communications. 2012;7(8). doi:10.1177/1934578X1200700822spa
dc.identifier.issn1934-578X-
dc.identifier.urihttps://hdl.handle.net/10495/41216-
dc.description.abstractABSTRACT: The syntheses of combretastatin A-4 from gallic acid and of three combretastatin-based hybrids are described. Starting from commercial gallic acid, thephosphonium salt (3,4,5-trimethoxybenzylphosphonium bromide) is synthesized and coupled, through a Wittig reaction, with several aldehydes, includingmethoxymethyl-protected isovanillin, the aldehyde γ-bicyclohomofarnesal having a labdane skeleton, 3-(3-pyridyl) propanal, and furfural. The biologicalproperties of the cis-coupled compounds as cytotoxic, antiviral and antifungal agents are also reported. In addition, pyrogallol, gallic and 3,4,5-trimethoxybenzoic acids have been studied biologically.spa
dc.format.extent6 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherSAGE Publicationsspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/co/*
dc.titleSynthesis and biological evaluation of combretastatin A-4 and three combretastatin-based hybridsspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGRID - Grupo de Investigación Dermatológicaspa
dc.identifier.doi10.1177/1934578X1200700822-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1555-9475-
oaire.citationtitleNatural product communicationsspa
oaire.citationstartpage1051spa
oaire.citationendpage1056spa
oaire.citationvolume7spa
oaire.citationissue8spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc/4.0/spa
dc.publisher.placeWesterville, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsAntifúngicos-
dc.subject.decsAntifungal Agents-
dc.subject.decsAntivirales-
dc.subject.decsAntiviral Agents-
dc.subject.decsBiología Molecular-
dc.subject.decsMolecular Biology-
dc.subject.decsEstilbenos-
dc.subject.decsStilbenes-
dc.description.researchgroupidCOL0050839spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000935-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000998-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008967-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D013267-
dc.relation.ispartofjournalabbrevNat. Prod. Commun.spa
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