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dc.contributor.authorHiguita David, Edwin Andrés-
dc.contributor.authorJaimes Barragán, Fabián Alberto-
dc.contributor.authorRugeles López, María Teresa-
dc.contributor.authorMontoya Guarín, Carlos Julio-
dc.date.accessioned2017-09-27T15:39:29Z-
dc.date.available2017-09-27T15:39:29Z-
dc.date.issued2013-
dc.identifier.citationHiguita EA, Jaimes FA, Rugeles MT, Montoya CJ. In vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4. AIDS Res Ther. 2013;10(10): 1-12. doi: 10.1186/1742-6405-10-10.spa
dc.identifier.issn1742-6405-
dc.identifier.urihttp://hdl.handle.net/10495/8361-
dc.description.abstractABSTARCT: During the HIV-1 replication cycle, several molecules including chemokine receptors and cholesterol are crucial, and are therefore potential targets for therapeutic intervention. Indeed statins, compounds that inhibit cellular synthesis of cholesterol and have anti-inflammatory and immunomodulatory properties were shown to inhibit HIV-1 infection by R5 tropic strains but not by X4 strains in vitro, mainly by altering the chemokine receptor/ligands axes. Therefore, the objective of this study was to characterize in vivo, the capacity of statins to modulate in HIV seronegative and chronically HIV-1-infected adults the expression of CCR5 and CXCR4, of their ligands and the tropism of circulating HIV-1 strainsspa
dc.format.extent11spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBioMed Centralspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsAtribución 2.5*
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.subjectHIV infection-
dc.subjectStatins-
dc.subjectCCR5-
dc.subjectCXCR4-
dc.subjectViral tropism-
dc.subjectChemokines-
dc.subjectEstatinas-
dc.titleIn vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4spa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupInmunovirologíaspa
dc.identifier.doi10.1186/1742-6405-10-10-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1742-6405-
oaire.citationtitleAIDS Research and Therapyspa
oaire.citationstartpage1spa
oaire.citationendpage12spa
oaire.citationvolume10spa
oaire.citationissue1spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeReino Unidospa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.relation.ispartofjournalabbrevAIDS Res Therspa
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