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dc.contributor.authorBetancur Galvis, Liliana Amparo-
dc.contributor.authorCheca, Javier-
dc.contributor.authorMarco Ventura, Juan Alberto-
dc.contributor.authorEstornell, Ernesto-
dc.date.accessioned2017-10-10T16:53:50Z-
dc.date.available2017-10-10T16:53:50Z-
dc.date.issued2003-
dc.identifier.citationBetancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178.spa
dc.identifier.issn0032-0943-
dc.identifier.urihttp://hdl.handle.net/10495/8522-
dc.description.abstractABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC50) value of 5.1 ± 0.2 µM. In the present study, some structure-activity trends are suggested for the inhibitory activity of these natural products on the mammalian mitochondrial respiratory chain.spa
dc.format.extent1spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherGeorg Thieme Verlagspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsAtribución 2.5*
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.subjectJatrophane Diterpenes-
dc.subjectLátex de euphorbia obtusifolia-
dc.subjectActividad inhibitoria-
dc.subjectCadena respiratoria mitocondrial-
dc.titleJatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chainspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupCentro de de Investigaciones Dermatologicasspa
dc.publisher.groupInfección y Cáncerspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1439-0221-
oaire.citationtitlePlanta Medicaspa
oaire.citationstartpage177spa
oaire.citationendpage178spa
oaire.citationvolume69spa
oaire.citationissue2spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeAlemaniaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.relation.ispartofjournalabbrevPlanta Medspa
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