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https://hdl.handle.net/10495/11994| Título : | Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents |
| Autor : | Pabón Vidal, Adriana Lucía Gil, Ana Gloria Galiano, Silvia Perez Silanes, Silvia Daharo, Eric Monge, Antonio Aldana, Ignacio Burguete, Asunción |
| metadata.dc.subject.*: | Antimalarial agents Brimonidine Tartrate Chalcone Plasmodium falciparum Quinoxaline Tartrato de Brimonidina |
| Fecha de publicación : | 2014 |
| Editorial : | MDPI |
| Citación : | Gil A, Pabón A, Galiano S, Burguete A, Pérez-Silanes S, Deharo E, Monge A, Aldana I. Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents. Molecules. 2014 Feb 18;19(2):2166-80 |
| Resumen : | ABSTARCT: We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring. Keywords: Plasmodium falciparum; antimalarial agents; quinoxaline; quinoxaline 1,4-di-N-oxide; chalcone |
| ISSN : | 1420-3049 |
| metadata.dc.identifier.doi: | 10.3390/molecules19022166 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| PabonVidal Adriana_2014_BiologicalQuinoxalinePlasmodium.pdf | Artículo de investigación | 266.51 kB | Adobe PDF | Visualizar/Abrir |
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