The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine

Varela Miranda, Rubén Eduardo; Mollinedo Gajate, Cristina; Muro, Antonio; Mollinedo, Faustino

doi:10.1016/j.actatropica.2013.11.018

Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/33047

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Varela Miranda, Rubén Eduardo	-
dc.contributor.author	Mollinedo Gajate, Cristina	-
dc.contributor.author	Muro, Antonio	-
dc.contributor.author	Mollinedo, Faustino	-
dc.date.accessioned	2022-12-27T12:42:46Z	-
dc.date.available	2022-12-27T12:42:46Z	-
dc.date.issued	2014	-
dc.identifier.citation	Varela-M RE, Mollinedo-Gajate C, Muro A, Mollinedo F. The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine. Acta Trop. 2014 Mar;131:32-6. doi: 10.1016/j.actatropica.2013.11.018.	spa
dc.identifier.issn	0001-706X	-
dc.identifier.uri	https://hdl.handle.net/10495/33047	-
dc.description.abstract	ABSTRACT: HSP90 is an abundant protein in Leishmania parasites that plays a major role in the parasite survival under stress conditions. Here we found that the HSP90 inhibitor 17- AAG (≥100 nM 17-AAG) induced cell cycle arrest at G0/G1 in L. infantum and L. panamensis promastigotes, and highly potentiated the induction of cell death by an apoptotic-like process mediated by the ether phospholipid edelfosine (5-20 μM). These data suggest that the combined treatment of 17-AAG and edelfosine might be a novel and effective approach of combination therapy in the treatment of leishmaniasis.	spa
dc.format.extent	21	spa
dc.format.mimetype	application/pdf	spa
dc.language.iso	eng	spa
dc.publisher	Elsevier	spa
dc.type.hasversion	info:eu-repo/semantics/acceptedVersion	spa
dc.rights	info:eu-repo/semantics/openAccess	spa
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/2.5/co/	*
dc.title	The HSP90 inhibitor 17-AAG potentiates the antileishmanial activity of the ether lipid edelfosine	spa
dc.type	info:eu-repo/semantics/article	spa
dc.publisher.group	Programa de Estudio y Control de Enfermedades Tropicales (PECET)	spa
dc.identifier.doi	10.1016/j.actatropica.2013.11.018	-
oaire.version	http://purl.org/coar/version/c_ab4af688f83e57aa	spa
dc.rights.accessrights	http://purl.org/coar/access_right/c_abf2	spa
dc.identifier.eissn	1873-6254	-
oaire.citationtitle	Acta Tropica	spa
oaire.citationstartpage	1	spa
oaire.citationendpage	21	spa
oaire.citationvolume	131	spa
dc.rights.creativecommons	https://creativecommons.org/licenses/by-nc-nd/4.0/	spa
dc.publisher.place	Ámsterdam, Países Bajos	spa
dc.type.coar	http://purl.org/coar/resource_type/c_2df8fbb1	spa
dc.type.redcol	https://purl.org/redcol/resource_type/ART	spa
dc.type.local	Artículo de investigación	spa
dc.subject.decs	Proteínas HSP90 de Choque Térmico	-
dc.subject.decs	HSP90 Heat-Shock Proteins	-
dc.subject.decs	Puntos de Control del Ciclo Celular	-
dc.subject.decs	Cell Cycle Checkpoints	-
dc.subject.decs	Leishmania	-
dc.subject.decs	Leishmania infantum	-
dc.subject.decs	Apoptosis	-
dc.subject.decs	Benzoquinonas	-
dc.subject.decs	Benzoquinones	-
dc.subject.decs	Relación Dosis-Respuesta a Droga	-
dc.subject.decs	Dose-Response Relationship, Drug	-
dc.subject.decs	Quimioterapia Combinada	-
dc.subject.decs	Drug Therapy, Combination	-
dc.subject.decs	Éteres Fosfolípidos	-
dc.subject.decs	Phospholipid Ethers	-
dc.subject.decs	Proteínas Protozoarias	-
dc.subject.decs	Protozoan Proteins	-
dc.subject.decs	Fase de Descanso del Ciclo Celular	-
dc.subject.decs	Resting Phase, Cell Cycle	-
dc.description.researchgroupid	COL0015099	spa
dc.relation.ispartofjournalabbrev	Acta. Trop.	spa
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