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https://hdl.handle.net/10495/36725| Título : | Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. |
| Autor : | Miranda Angulo, Ana Lucia Lee, Daniel A. Bedont, Joseph L. Pak, Thomas Wang, Hong Song, Juan Takiar, Vani Charubhumi, Vanessa Balordi, Francesca Takebayashi, Hirohide Aja, Susan Ford, Eric Fishell, Gordon Blackshaw, Seth |
| metadata.dc.subject.*: | Neurogénesis Hipotálamo Hypothalamus Peso corporal Body Weight Bromodesoxiuridina Bromodeoxyuridine Dieta alta en grases Diet hight fat Eminencia Media Median Eminence Ratones endogámicos C57BL Mice, Inbred C57BL Receptores de estrógeno Receptors, Estrogen Tamoxifeno Tamoxifen |
| Fecha de publicación : | 2012 |
| Editorial : | Nature Research |
| Citación : | Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012 Mar 25;15(5):700-2. doi: 10.1038/nn.3079. PMID: 22446882; PMCID: PMC3380241. |
| Resumen : | ABSTRACT:Adult hypothalamic neurogenesis has been recently reported, but the cell of origin and function of these newborn neurons are unknown. We utilize genetic fate mapping to show that median eminence tanycytes generate newborn neurons; blocking this neurogenesis alters weight and metabolic activity in adult mice. These findings describe a previously unreported neurogenic niche within the mammalian hypothalamus with important implications for metabolism. |
| metadata.dc.identifier.eissn: | 1546-1726 |
| ISSN : | 1097-6256 |
| metadata.dc.identifier.doi: | 10.1038/nn.3079 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| MirandaAngulo_2012_TanycytesHypothalamic.pdf | Articulo de investigación | 820.05 kB | Adobe PDF | Visualizar/Abrir |
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