Por favor, use este identificador para citar o enlazar este ítem:
https://hdl.handle.net/10495/38198| Título : | Biological evaluation of aromatic compounds as B-Lactamase inhibitors |
| Autor : | Arango Acosta, Gabriel Jaime Jaramillo Flórez, María Consuelo Mora Arango, Cristina Lucía Vélez, Luis Esteban Quijano Tobón, Jairo |
| metadata.dc.subject.*: | beta-Lactamasas beta-Lactamases Ácido Clavulánico Clavulanic Acid Inhibidores Enzimáticos Enzyme Inhibitors Amoxicilina Amoxicillin Chalcona Chalcone https://id.nlm.nih.gov/mesh/D001618 https://id.nlm.nih.gov/mesh/D019818 https://id.nlm.nih.gov/mesh/D004791 https://id.nlm.nih.gov/mesh/D000658 https://id.nlm.nih.gov/mesh/D002599 |
| Fecha de publicación : | 2006 |
| Editorial : | University of Salerno |
| Resumen : | ABSTRACT: The appearance of bacterial resitance due to β-lactamase enzyme is frequent in Colombia and it has important consequences in term of morbidity and mortality. The inhibitory evaluation of the β-lactamase enzyme of 5 compounds gave as a result more powerful compounds than clavulanic acid. The more active chalcones establish hydrogen bonds with Ser, Tyr and Lys amino acids, the high number of hydrogen bonds between the compound and the amino acid increases the affinity and the inhibitory activity. In accordance with the results, the compounds might inhibit irreversibly the β-lactamase enzyme. |
| ISSN : | 1827-8620 |
| Aparece en las colecciones: | Artículos de Revista en Farmacéutica y Alimentarias |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| JaramilloConsuelo_2006_Biological_Evaluation_Aromatic.pdf | Artículo de investigación | 128.53 kB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons
