Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/12041
Título : Comparative antioxidant, antiproliferative and apoptotic effects of Ilex laurina and Ilex paraguariensis on colon cancer cells
Autor : Pérez Cardona, Juan Manuel
Maldonado Celis, María Elena
Rojano, Benjamín Alberto
Alzate Guarín, Fernando
Sáez Vega, Jairo
Cardona Galeano, Wilson
Palabras clave : Ilex laurina
Ilex paraguariensis
Antioxidant
Antiproliferative
Apoptosis
Colon cancer
Fecha de publicación : 2014
Editorial : University of Benin
Citación : Pérez-Cardona J, Maldonado-Celis M, Rojano B, Alzate-Guarín F, Sáez-Vega J, Cardona-Galeano W. Comparative antioxidant, antiproliferative and apoptotic effects of Ilex laurina and Ilex paraguariensis on colon cancer cells. Trop J Pharm Res. 2014; 13(8): 1279-86. DOI: 10.4314/tjpr.v13i8.12
Abstract : Purpose: To determine and compare the antioxidant, antiproliferative and apoptotic effects of leaf infusions of Ilex laurina and Ilex paraguariensis in colon cancer cells. Methods: Antioxidant activity was determined by ORAC (Oxygen Radical Absorbance Capacity) and FRAP (Ferric Reducing Antioxidant Power). Cytotoxic and antiproliferative effects were analyzed using MTT ((3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) and sulfhorodamine-B respectively. Cell death and apoptosis of human colon adenocarcinoma cells SW480 and their metastatic-derived SW620 cells, were analyzed by flow cytometry using propidium iodide and Annexin-V. Results: Although their flavonoid levels were similar, I. laurina infusion contained 2.2 and 4.4 times higher amounts of total phenolic and caffeoyl derivatives, respectively, than I. paraguariensis. FRAP and ORAC values for I. laurina infusion were 1.6 and 2.0 more active than I. paraguariensis. Both plant infusions inhibited viability and cell growth of SW480 and SW620 cells. These results may be associated to cell cycle-arrest and apoptosis because of the comparable increase of hypodiploid and annexin-V positive colon cancer cells. Conclusion: These data highlight the antioxidant and promising anticancer activities of I. laurina and Ilex paraguariensis.
Grupo de INV. : Grupo de Estudios Botánicos
Impacto de Componentes Alimentarios en la Salud
URI : http://hdl.handle.net/10495/12041
ISSN : 15965996
15969827 E
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
PerezJuan_2014_ComparativeAntioxidantAntiproliferativeApoptotic.pdfArticulo de revista1,78 MBAdobe PDFVisualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons

 


Gestión de T.I. /Sistema de Bibliotecas / Universidad de Antioquia / Cl. 67 Nº 53 - 108 - Bloque 8 Conmutador: 219 51 51- 219 51 40 comunicacionessistemadebibliotecas@udea.edu.co Medellín - Colombia