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https://hdl.handle.net/10495/26208| Título : | Mutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailand |
| Autor : | Galy, Oliver Chemin, Isabelle Le Roux, Emilie Villar, Stephanie Le Calvez Kelm, Florence Lereau, Myriam Gouas, Doriane Vieco, Beatriz Suárez Mellado, Iris Navas Navas, María Cristina Chevallier, Michele Norder, Helene Srivatanakul, Petcharin Karalak, Anant Sangrajrang, Suleeporn Trepo, Christian Hainaut, Pierre |
| metadata.dc.subject.*: | Patología Molecular Pathology, Molecular Virus de la Hepatitis B Hepatitis B virus Genes p53 Genes, p53 Hepacivirus |
| Fecha de publicación : | 2011 |
| Editorial : | Hindawi Pub. Corp. |
| Resumen : | ABSTRACT: Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development. |
| metadata.dc.identifier.eissn: | 2090-1372 |
| ISSN : | 2090-1364 |
| metadata.dc.identifier.doi: | 10.1155/2011/697162 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| GalyOliver_2011_.pdf | Artículo de investigación | 3.49 MB | Adobe PDF | Visualizar/Abrir |
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