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https://hdl.handle.net/10495/36450| Título : | Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studies |
| Autor : | Bedoya Berrio, Gabriel De Jesus Ruiz Linares, Andrés Service, Susan Deyoung, Joseph Karayiorgou, María Pretoriuos, Herman Bedoya, Gabriel Ospina Duque, Jorge Macedo, António Palha, Joana Almeida Heutink, Peter Aulchenko, Yurii Oostra, Ben Van Duijn, Cornelia Jarvelin, Marjo Riitta Varilo, Teppo Peddle, Lynette Rahman, Proton Murray, Sarah Galver, Luana Peltonen, Leena Sabatti, Chiara Collins, Andrew Freimer, Nelson |
| metadata.dc.subject.*: | Cromosomas Humanos Par 22 Chromosomes, Human, Pair 22 Genética de Población Genetics, Population Genoma Humano Genome, Human Desequilibrio de Ligamiento Linkage Disequilibrium Polimorfismo de Nucleótido Simple Polymorphism, Single Nucleotide |
| Fecha de publicación : | 2006 |
| Editorial : | Nature Research |
| Citación : | Service S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A, Macedo A, Palha JA, Heutink P, Aulchenko Y, Oostra B, van Duijn C, Jarvelin MR, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L, Sabatti C, Collins A, Freimer N. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet. 2006 May;38(5):556-60. doi: 10.1038/ng1770. Epub 2006 Apr 2. PMID: 16582909. |
| Resumen : | ABSTRACT: The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping. |
| metadata.dc.identifier.eissn: | 1546-1718 |
| ISSN : | 1061-4036 |
| metadata.dc.identifier.doi: | 10.1038/ng1770 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| BedoyaGabriel_2006_MagnitudeDistributionLinkage.pdf | Articulo de investigación | 338.67 kB | Adobe PDF | Visualizar/Abrir |
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