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https://hdl.handle.net/10495/41107| Título : | Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model |
| Autor : | Balcázar Morales, Norman Gutiérrez Gómez, Gustavo Adolfo Giraldo Dávila, Deisy Combariza Montanez, Marianny Yajaira Holzgrabe, Ulrike Tabares Guevara, Jorge Humberto Ramírez Pineda, José Robinson Acín Martínez, Sergio Muñoz Herrera, Diana Lorena Montoya Pelaéz, Guillermo León |
| metadata.dc.subject.*: | Adipose Tissue Tejido Adiposo Biomarkers Biomarcadores Body Weight Peso Corporal Carbohydrate Metabolism Metabolismo de los Hidratos de Carbono Diet, High-Fat Dieta Alta en Grasa Disease Models, Animal Modelos Animales de Enfermedad Gene Expression Regulation Regulación de la Expresión Génica Insulin Secretion Secreción de Insulina Liver Hígado Obesity Obesidad Organ Size Tamaño de los Órganos Triterpenes Triterpenos https://id.nlm.nih.gov/mesh/D000273 https://id.nlm.nih.gov/mesh/D015415 https://id.nlm.nih.gov/mesh/D001835 https://id.nlm.nih.gov/mesh/D050260 https://id.nlm.nih.gov/mesh/D059305 https://id.nlm.nih.gov/mesh/D004195 https://id.nlm.nih.gov/mesh/D005786 https://id.nlm.nih.gov/mesh/D000078790 https://id.nlm.nih.gov/mesh/D008099 https://id.nlm.nih.gov/mesh/D009765 https://id.nlm.nih.gov/mesh/D009929 https://id.nlm.nih.gov/mesh/D014315 |
| Fecha de publicación : | 2020 |
| Editorial : | MDPI |
| Citación : | Gutiérrez G, Giraldo-Dávila D, Combariza MY, Holzgrabe U, Tabares-Guevara JH, Ramírez-Pineda JR, Acín S, Muñoz DL, Montoya G, Balcazar N. Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model. Molecules. 2020 Mar 25;25(7):1486. doi: 10.3390/molecules25071486. |
| Resumen : | ABSTRACT: Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported. |
| metadata.dc.identifier.eissn: | 1420-3049 |
| metadata.dc.identifier.doi: | 10.3390/molecules25071486 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| BalcazarNorman_2020_Serjanic_Acid_Improves.pdf | Artículo de investigación | 1.99 MB | Adobe PDF | Visualizar/Abrir |
| BalcazarNorman_2020_Serjanic_Acid_Improves.epub | Artículo de investigación | 4.24 MB | EPUB | Visualizar/Abrir |
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