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https://hdl.handle.net/10495/41551| Título : | Nanobioconjugates for targeted delivery of antigenic and therapeutic peptides at colorectal cancer |
| Autor : | Urrea Tavera, Cristian Stalyn Mejía de los Ríos, Susana Pamela Orozco Holguín, Jahir |
| metadata.dc.subject.*: | Neoplasias Colorrectales Colorectal Neoplasms Péptidos Peptides Antígenos Antigens Nanopartículas Nanoparticles Copolímero de Ácido Poliláctico-Ácido Poliglicólico Polylactic Acid-Polyglycolic Acid Copolymer Receptores CCR Receptors, CCR Nanobioconjugado https://id.nlm.nih.gov/mesh/D015179 https://id.nlm.nih.gov/mesh/D010455 https://id.nlm.nih.gov/mesh/D000941 https://id.nlm.nih.gov/mesh/D053758 https://id.nlm.nih.gov/mesh/D000077182 https://id.nlm.nih.gov/mesh/D054388 |
| metadata.dc.contributor.conferencename: | International Student Congress Of (bio)Medical Sciences, ISCOMS 2024 (del 3 al 7 de junio de 2024 : University Medical Center Groningen, Groningen, Países Bajos) |
| Fecha de publicación : | 4-jun-2024 |
| Resumen : | ABSTRACT: Colorectal cancer (CRC) presents challenges due to the limited effectiveness and side effects of conventional treatments like chemotherapy and surgery. Nanobioconjugates, such as poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs), offer improved drug delivery alternatives. Peptides bonded to CRC receptors show potential as therapies and vaccines. This study encapsulates the P1 peptide in PLGA-PEG-Mal NPs, functionalized with the G3 peptide for targeted CRC cell delivery to inhibit cell proliferation1,2, and encapsulates the P2 peptide in PLGA-COOH polymer to inhibit tumor growth via CD8+ T-cell activation, using D-mannosamine for targeting antigen-presenting cells 3,4. By studying the physicochemical properties of PLGA and peptides, the research aims to enhance stability and controlled release while minimizing side effects and improving CRC therapy from nanobioconjugates and peptide synergies. |
| Aparece en las colecciones: | Documentos de conferencias en Ciencias Exactas y Naturales |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| UrreaCristian_2024_Nanobioconjugates_Targeted_Antigenic.pdf | Póster de conferencia | 925.12 kB | Adobe PDF | Visualizar/Abrir |
| UrreaCristian_2024_Nanobioconjugates_Targeted_Antigenic-Resumen.pdf | Resumen | 145.62 kB | Adobe PDF | Visualizar/Abrir |
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