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https://hdl.handle.net/10495/43348| Título : | The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response |
| Autor : | Miranda Brand, Yaneth Bedoya, Astrid Milena Betancur Galvis, Liliana Amparo Gallego Gómez, Juan Carlos |
| metadata.dc.subject.*: | Virus Zika Zika Virus Flavivirus Antivirales Antiviral Agents Próstata Prostate Infección por el Virus Zika Zika Virus Infection https://id.nlm.nih.gov/mesh/D000071244 https://id.nlm.nih.gov/mesh/D005416 https://id.nlm.nih.gov/mesh/D000998 https://id.nlm.nih.gov/mesh/D011467 https://id.nlm.nih.gov/mesh/D000071243 |
| Fecha de publicación : | 2022 |
| Editorial : | MDPI |
| Citación : | Miranda Brand Y, Bedoya AM, Betancur-Galvis L, Gallego-Gómez JC. The Colombian Zika Virus Isolate (COL345Si) Replicates in Prostate Adenocarcinoma Cells and Modulates the Antiviral Response. Microorganisms. 2022 Dec 7;10(12):2420. doi: 10.3390/microorganisms10122420. |
| Resumen : | ABSTRACT: Zika virus (ZIKV), a flavivirus that is mainly transmitted by A. aegypti and A. albopictus and sexual transmission, has been documented and described. The ZIKV RNA detection in the semen of vasectomized men indicates that accessory glands such as the prostate could be a site of virus replication. In this study, we characterized the ZIKV infection, evaluated the antiviral profile, and demonstrated the AXL and TIM-1 expression on the PC3 prostate cell line. It was also determined that PC3 cells are susceptible and permissive to ZIKV infection without altering the cell viability or causing a cytopathic effect. The antiviral profile suggests that the PC3 cells modulate the antiviral response through the suppressor molecule expression, SOCS-1, during a ZIKV infection |
| metadata.dc.identifier.eissn: | 2076-2607 |
| metadata.dc.identifier.doi: | 10.3390/microorganisms10122420 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| MirandaYaneth_2022_Colombian_Zika_Virus.pdf | MirandaYaneth_2022_Colombian_Zika_Virus | 1.92 MB | Adobe PDF | Visualizar/Abrir |
| MirandaYaneth_2022_Colombian_Zika_Virus.epub | MirandaYaneth_2022_Colombian_Zika_Virus | 4.38 MB | EPUB | Visualizar/Abrir |
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