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https://hdl.handle.net/10495/8522| Título : | Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain |
| Autor : | Betancur Galvis, Liliana Amparo Checa, Javier Marco Ventura, Juan Alberto Estornell, Ernesto |
| metadata.dc.subject.*: | Jatrophane Diterpenes Látex de euphorbia obtusifolia Actividad inhibitoria Cadena respiratoria mitocondrial |
| Fecha de publicación : | 2003 |
| Editorial : | Thieme Gruppe |
| Citación : | Betancur Galvis, L. A., Checa, J., Marco Ventura, J. A., & Estornell, E. Jatrophane diterpenes from the latex of euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Planta Médica. 2003; 69: 177-178. |
| Resumen : | ABSTARCT: Seven diterpenes isolated of the latex of the Euphorbia obtusifolia were evaluated as inhibitors of the NADH oxidase activity in submitochondrial particles from bovine heart. Compound 2,2,3,5,7,8,9,15-heptahydroxyjatropha-6(17),11-diene-14-one 8,9-diacetate 7-isobutyrate 2.3-bis(2-methylbutyrate), was the most potent inhibitor with an inhibitory concentration (IC50) value of 5.1 ± 0.2 µM. In the present study, some structure-activity trends are suggested for the inhibitory activity of these natural products on the mammalian mitochondrial respiratory chain. |
| metadata.dc.identifier.eissn: | 1439-0221 |
| ISSN : | 0032-0943 |
| metadata.dc.identifier.doi: | 10.1055/s-2003-37701 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| BetancurLiliana_2003_ JatrophaneDiterpenesLatex.pdf | Artículo de revista | 70.33 kB | Adobe PDF | Visualizar/Abrir |
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