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https://hdl.handle.net/10495/41216| Título : | Synthesis and biological evaluation of combretastatin A-4 and three combretastatin-based hybrids |
| Autor : | Agudelo Goméz, Lee Solbay Tangarife Castaño, Verónica Betancur Galvis, Liliana Amparo Zapata Londoño, María Bibiana Pérez Guaita, David González, Miguel |
| metadata.dc.subject.*: | Antifúngicos Antifungal Agents Antivirales Antiviral Agents Biología Molecular Molecular Biology Estilbenos Stilbenes https://id.nlm.nih.gov/mesh/D000935 https://id.nlm.nih.gov/mesh/D000998 https://id.nlm.nih.gov/mesh/D008967 https://id.nlm.nih.gov/mesh/D013267 |
| Fecha de publicación : | 2012 |
| Editorial : | SAGE Publications |
| Citación : | González MA, Pérez-Guaita D, Agudelo-Goméz LS, Tangarife-Castaño V, Zapata B, Betancur-Galvis L. Synthesis and Biological Evaluation of Combretastatin A-4 and Three Combretastatin-Based Hybrids. Natural Product Communications. 2012;7(8). doi:10.1177/1934578X1200700822 |
| Resumen : | ABSTRACT: The syntheses of combretastatin A-4 from gallic acid and of three combretastatin-based hybrids are described. Starting from commercial gallic acid, thephosphonium salt (3,4,5-trimethoxybenzylphosphonium bromide) is synthesized and coupled, through a Wittig reaction, with several aldehydes, includingmethoxymethyl-protected isovanillin, the aldehyde γ-bicyclohomofarnesal having a labdane skeleton, 3-(3-pyridyl) propanal, and furfural. The biologicalproperties of the cis-coupled compounds as cytotoxic, antiviral and antifungal agents are also reported. In addition, pyrogallol, gallic and 3,4,5-trimethoxybenzoic acids have been studied biologically. |
| metadata.dc.identifier.eissn: | 1555-9475 |
| ISSN : | 1934-578X |
| metadata.dc.identifier.doi: | 10.1177/1934578X1200700822 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| BetancurLiliana_2012_Antifungal_Activity_Cytotoxic.pdf | Artículo de investigación | 391.23 kB | Adobe PDF | Visualizar/Abrir |
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